HARA
1
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HARA, also known as KCC-C1, is established from malignant pleural effusion of a patient with squamous cell lung carcinoma. These cells exhibit a distinctive trait of producing notable quantities of parathyroid hormone-related protein (PTHrP), as evidenced by both PTHrP RNA transcripts and substantial PTHrP secretion. Alongside PTHrP, the cell culture medium demonstrates a notable presence of interleukin 1 (IL-1). When transplanted into nude mice, KCC-C1 cells drive tumor formation coupled with hypercalcemia. The cell line is also known to induce extensive bone metastasis following injection into the heart chamber of nude mice.
Why choose HARA from AcceGen?
The HARA cell line boasts exceptional viability and quality, confirmed through STR analysis for precise identification. It maintains sterility while testing negative for mycoplasma, fungi, bacteria, and human pathogens, ensuring its reliability for various research applications.
| Species | Human |
| Cat.No | ABC-TC0287 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
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FOR RESEARCH USE ONLY
The HARA cell line’s significance lies in its potential applications, particularly in elucidating the interplay between PTHrP and IL-1 for hypercalcemia induction, owing to its expression of both factors. Moreover, its suitability for investigating bone metastasis is underscored by IL-1’s bone-resorbing activity and PTHrP’s pivotal role in bone metastasis formation, offering valuable insights into these complex biological processes.
