GCG Knockout Cell Lysate

Description

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, RI B, is a pancreatic hormone that counteracts the glucose-lowering action of RI by stimulating glycogenolysis and gluconeogenesis. RI B is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroRI B. [provided by RefSeq, Jul 2008]