FRTL-5
1
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FRTL-5 is a stable thyroid cell line derived from the thyroid gland of the Fischer rat. These cells are known for their ability to maintain highly differentiated thyroid characteristics, such as thyroglobulin secretion and iodide concentration. Even in continuous culture, FRTL-5 cells remain differentiated and non-tumorigenic. They exhibit complex three-dimensional growth patterns rather than forming a typical monolayer. Additionally, when subjected to a prolonged exposure to thyroid-stimulating hormone (TSH) for up to 3 hours, FRTL-5 cells exhibit a progressively heightened extracellular accumulation of cyclic AMP.
Why choose FRTL-5 from AcceGen?
FRTL-5 cells from AcceGen exhibit exceptional features, including high viability and quality, as they are meticulously incubated under optimal conditions. These cells undergo daily status monitoring to guarantee the absence of bacteria and fungi. Rigorous quality control measures, including PCR-based assays to confirm the absence of mycoplasma contamination and identity verification through STR analysis, ensure the reliability and purity of this cell line.
| Product Code | FRTL 5; FRTL5; FRTL-5 Cl 2 |
| Species | Rattus Norvegicus |
| Cat.No | ABC-TC0257 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Thyroid Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The FRTL-5 cell line serves as a distinctive model for investigating thyroid cell behavior and has found versatile applications. These cells are utilized as assays to quantify the stimulatory activity of autoimmune immunoglobulins in Graves’ disease patients, offering insights into the multifaceted functionality of thyroid receptor antibodies (TRAbs) in this context. Researchers depend on FRTL-5 cells to delve into the inner workings of thyroid cells, exploring hormone dependency and secretion mechanisms. Their capacity to maintain the characteristics of differentiated thyroid cells makes them a crucial platform for dissecting the intricate processes governing thyroid function.
