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| Product Code | FRTL 5; FRTL5; FRTL-5 Cl 2 |
| Species | Rattus Norvegicus |
| Cat.No | ABC-TC0257 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Thyroid Cell Lines |
FRTL-5 is a thyroid epithelial cell line derived from the normal thyroid gland of a 5- to 6-week-old Fischer rat. Unlike typical thyroid follicular cells, FRTL-5 grows in adherent clusters with a distinctive three-dimensional architecture featuring, characterized by raised central aggregates. Their proliferation is strictly thyroid-stimulating hormone (TSH)-dependent, with a doubling time of 36 ± 6 hours. Karyotype analyses indicate diploid characteristics, typically ranging from 37 to 40 chromosomes. FRTL-5 cells are non-tumorigenic in vivo. This cell line serves as a unique model for studying thyroid hormone synthesis and regulatory pathways, reflecting physiological behaviors absent in cancerous counterparts.
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The FRTL-5 is a robust and widely used model for exploring thyroid physiology and endocrine regulation. It enables in-depth investigation into TSH-regulated processes, including iodide uptake, thyroglobulin synthesis, and sodium-iodide symporter (NIS) activity. FRTL-5 is also used to study the molecular mechanisms of autoimmune thyroid diseases, thyroid hormone metabolism, and the effects of endocrine-disrupting chemicals on thyroid homeostasis. Its non-malignant phenotype and hormone-dependent growth make it particularly suitable for screening thyroid-targeted therapeutics and for modeling conditions such as hypothyroidism and iodine deficiency.
