For research use only
| Cat No. | ABC-TC0244 |
| Product Type | Mouse Lymphoma Cell Lines |
| Cell Type | Lymphoblast |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Disease | Lymphoma |
| Product Code | EL4NOB1; NOB-1 |
EL4.NOB-1 mouse lymphoma cells with IL-1R expression for immunology studies, cytokine signaling, and TGF-β resistance research.
EL4. NOB-1 is a murine precursor T-cell lymphoblastic lymphoma line derived from ascitic tumor fluid of C57BL/6N mice following chemical induction of lymphoma. These cells grow non-adherently in suspension, display lymphoblast morphology, and can be continuously passaged in vitro. Derived as a subclone from the parental EL4. BU. OU6 line, EL4. NOB-1 cells express high levels of interleukin-1 (IL-1) receptors and demonstrate resistance to agents such as bromodeoxyuridine and ouabain. They express characteristic T-cell markers of murine lymphomas and exhibit functional IL-1β signaling, which modulates IL-2 production and imparts partial resistance to TGF-β via MAPK, PKA, and PLC signaling pathways. EL4. NOB-1 cells are widely utilized in immunology research to study T-cell receptor biology, cytokine signaling, signal transduction mechanisms, and lymphoma pathophysiology.
| Product Code | EL4NOB1; NOB-1 |
| Species | Mouse |
| Cat.No | ABC-TC0244 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblast |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Disease | Lymphoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Lymphoma Cell Lines |
EL4. NOB-1 enables immunology research focused on IL-1 receptor signaling pathways and immune modulation. It models cytokine production through IL-1-induced IL-2 secretion, supporting pharmacological assays using enzyme inhibitors targeting PKC, PKA, MAPK, PLA2, PI-PLC, and PC-PLC. The cell line facilitates cellular growth, autoinduction, and TGF-β resistance studies while investigating IL-1-induced IL-2 suppression. Additionally, it advances signaling pathway analysis of IL-1 receptor activation and molecular biology research characterizing immune signaling genes and proteins.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
