Intestinal epithelial cells (IECs) are interconnected by tight junctions, forming a protective barrier in the gut that prevents the entry of harmful microorganisms, antigens, and toxins from the gut lumen into the bloodstream. The small intestinal epithelium primarily consists of terminally differentiated mucous and absorptive cells. While the small intestinal cells exhibit remarkable resistance to injury, any damaged cells undergo rapid apoptosis and are shed into the gut lumen. The replication and differentiation of intestinal epithelial cells exhibit distinct phenotypes, characterized by spatial boundaries. Cynomolgus monkeys have found extensive utility in predicting drug absorption in humans. AcceGen provides primary small intestinal epithelial cells derived from cynomolgus monkeys.
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