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COLO-800 is a human melanoma cell line, derived from a subcutaneous nodule of a 14-year-old boy with melanoma in 1990. The morphology of cells is fibroblast. Melanoma is the most dangerous type of skin cancer and develops from malignant transformations of the melanocytes. In human skin, melanocytes are found in the epidermis and hair follicles. The essential characteristic of these cells is the ability to produce melanin. Melanin has a complex of antioxidant and pro-oxidant properties. The pro-oxidant effects of melanin lead to increased levels of intracellular oxygen free radicals, which damage the DNA of melanocytes. These mutations lead to overactivation of various cell signaling pathways, such as MAPK pathway, and result in uncontrolled proliferation, dedifferentiation and immortalization of specific cell types.
Why choose COLO-800 from AcceGen?
COLO-800 cell line from AcceGen are tested and found to be free of mycoplasma, bacterial, viruses, and other microbes. All cells have high viability. The cell line is cultured in RPMI 1640 with 10% FBS. The cells were cryopreserved at about 5 × 106 cells.
| Product Code | COLO 800; COLO #800; COLO800; Colorado 800 |
| Species | Human |
| Cat.No | ABC-TC0172 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Cutaneous Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
COLO-800 cell line can be used as a tumor model to simulate melanoma, which is crucial for understanding the molecular mechanisms underlying melanoma tumorigenicity and treatment resistance. Researches on genetic pathways of this cell line may help identify genes related to the development of melanoma and provide a theoretical basis for diagnosis and treatment of hereditary melanoma.
