Chang Liver
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Chang liver cell line was originally thought to be derived from normal liver tissue, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via HeLa cell contamination.
The cell line that has come to be known as “Chang Liver” originated from the biopsy of a patient during an exploratory laparotomy in the early 1950s. In 1967, A researcher presented evidence that Chang Liver (among many other supposedly “unique” cell lines) displayed glucose-6-phosphate dehydrogenase (G6PD) and phosphoglucomutase (PGM) isoforms that were identical to HeLa cells (3). Chang liver cell line became known for its unique characteristics despite being contaminated with HeLa cells. Chang liver can be considered “notorious” because the contaminating cell line (the famous HeLa) is well known to the community, and because the misidentification of Chang liver has been known for more than half a century.
Why choose Chang Liver from AcceGen?
Epithelial-like Morphology: The Chang Liver Cell Line exhibits a distinctive epithelial-like morphology, ensuring relevance and accuracy in your experiments.
Versatile Applications: Unlock the potential for groundbreaking discoveries across a spectrum of research areas, including cell signaling pathways, drug screening, and liver-specific functions.
Quality Assurance: AcceGen prioritizes quality, ensuring sterility and reliability. The cell line undergoes rigorous testing, including assessments for bacterial, fungal, and Mycoplasma contamination, offering researchers peace of mind.
Trusted by Researchers: Join a community of researchers who trust AcceGen’s Chang Liver Cell Line for its consistent performance and contribution to advancements in biomedical research.
| Product Code | Chang liver; Chang Liver (HeLa derivative); Chang Cells; Chang; CHL |
| Species | Human |
| Cat.No | ABL-TC0127 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The “Chang Liver” cell line, also known as the “HeLa (Chang Liver)” cell line. Before 1967, it was used in scientific research as a model for liver cells in various experiments and studies. The application of the Chang Liver cell line was included investigations into liver cell biology, metabolism, and responses to different experimental conditions. In 1974, Nelson-Rees found that the “Chang Liver” cell line exhibited a group of distinctive chromosomes which were specific to the HeLa cell line The Chang Liver cell line is now recognized as a HeLa derivative.
