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| Species | Mouse |
| Cat.No | ABC-KH17916 |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Storage | Liquid Nitrogen |
| Product Type | Knockout Stable Cell Line |
CH12F3 is capable of cytokine-induced Ig heavy chain CSR. Key enzymes involved in DNA recombination and joining double strand breaks (DSBs), such as DNA Ligase 1, Ligase 3, Ligase 4 and Apyrimidinic Endonuclease APE1, have been knocked out in these CH12F3 cell lines, providing ideal genetic materials to investigate the roles of these proteins in regulating the proficient CSR event in mature B lymphocyte cell lines. Since enzymes involved in DNA metabolism play essential roles in embryogenesis, knockout of these proteins often resulted in lethality in mouse embryonic stem cells. However, knockout of these proteins in mature B cells are compatible with cell viability
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only
