demonstrate distinctive characteristics. These cells express CD4 and CD8, as well as CD1c, CD11b, CD11c, and CD14. Interestingly, LPS stimulation positively impacts CD1c expression in these cells. Notably, when exposed to LPS (TLR4 ligand), these canine dendritic cells show an upregulation of MHC II and costimulatory molecules, indicating an immune response. On the ultrastructural level, transmission electron microscopy reveals fine needle-like dendrites at the cellular periphery and dense granules resembling periodic microstructures, serving as a defining feature for identifying canine dendritic cells.
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