C6
1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
The C6 cell line, originating from a Wistar-Furth rat glioma induced by N-nitrosomethylurea exposure, maintains a glial cell phenotype characterized by fibroblast-like morphology. Genetically heterogeneous, these cells exhibit a wild-type p53 gene, elevated Rb gene expression, and a mutant p16/Cdkn2a/Ink4a locus with concomitant absence of p16 and p19ARF mRNA expression. Notably, C6 cells overexpress key genes implicated in human gliomas, including PDGF, IGF-1, EGFR, and Erb3/Her3 precursor proteins. Mirroring human gliomas, C6 cells manifest increased Ras pathway gene activity, under the regulatory influence of elevated Ras guanine triphosphate activator protein expression.
Why choose C6 from AcceGen?
C6 cells from AcceGen are characterized by their exceptional viability and quality, as they are meticulously incubated under optimal conditions and subject to daily monitoring for the absence of bacteria and fungi. Furthermore, a rigorous PCR-based assay is employed to verify the absence of mycoplasma contamination, and the cell line’s identity is confirmed through STR analysis, ensuring the reliability and integrity of these cells for various research applications.
| Product Code | C-6; C 6; RGC-6; RGC6; RGc6 |
| Species | Rat |
| Cat.No | ABC-TC0099 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Malignant Glioma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Nerve Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The C6 cell line is a crucial tool in glioma biology research, playing a pivotal role in modeling human gliomas and facilitating the exploration of novel therapeutic approaches. Frequently employed in neuro-oncology studies, C6 glioma cells are instrumental in generating animal models that faithfully replicate the features of human gliomas. This application enables the development of innovative therapeutic agents and strategies. Additionally, the C6 cell line excels in 3D cell culture and high-throughput screening, making it an indispensable resource for advancing our understanding of glioma pathogenesis and treatment.
