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C57BL/6 Mouse Liver Sinusoidal Endothelial Cells

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C57BL/6 Mouse Liver Sinusoidal Endothelial Cells from AcceGen are isolated from tissue of pathogen-free laboratory mice. Mouse Liver Sinusoidal Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in AcceGen's Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells […]
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Liver Sinusoidal Endothelial Cells
Product Code

MLSEC
Species

C57BL/6 Mouse
Cat.No

ABC-TC3208
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells

Description

C57BL/6 mouse liver sinusoidal endothelial cells are isolated from the liver tissue of adult C57BL/6 mice in vitro. They are positive for LYVE-1, CD32b, and Factor VIII, and negative for CD31 by immunofluorescence staining. Liver sinusoidal endothelial cells are non-parenchymal cells and form the hepatic sinusoids of liver. It’s a kind of specialized endothelial cell with unique morphology and functions. Liver sinusoidal endothelial cells (LSECs) represent a permeable barrier, with small pores in their structure creating a channel between the sinusoidal blood and the subendothelial space of Disse. C57BL/6 Mouse Liver Sinusoidal Endothelial CellsThe barrier formed by liver sinusoidal endothelial cells is also dynamic and functional, as it regulates the passage of a wide range of solutes and macromolecules between hepatocytes and bloodstream. Liver sinusoidal endothelial cells also have immune functions, which express the endocytic Fc-gamma receptor IIb2 (FcγRIIb2), various pattern recognition receptors (PRRs), scavenger receptors (SRs), and several toll-like receptors (TLRs).

 

Why choose C57BL/6 Mouse Liver Sinusoidal Endothelial Cells from AcceGen?

AcceGen prepares C57BL/6 mouse liver sinusoidal endothelial cells with caution to prevent any pathogens with our rigorous and standardized operation procedure, to give maximum performance in cell morphology, adherence rate, and cell viability.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

Kaminski, T. W., Katoch, O., Li, Z., Hanway, C. B., Dubey, R. K., Alagbe, A., Brzoska, T., Zhang, H., Sundd, P., Kato, G. J., Novelli, E. M., & Pradhan-Sundd, T. (2024). Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease. Haematologica, 109(5), 1535–1550.

Application

  • FOR RESEARCH USE ONLY

  • C57BL/6 mouse liver sinusoidal endothelial cells can be used in the research of liver regeneration. In the tubulogenesis assay, tubes and sprouts are generated by C57BL/6 mouse liver sinusoidal endothelial cells. When these cells are implanted in porous collagen scaffold, capillaries with lumen are formed. Liver sinusoidal endothelial cells can also form the spheroids expressing  vascular endothelial growth factor-A and C (VEGF-A, VEGF-C) and hepatocyte growth factor (HGF), which are essential for liver regeneration.

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  • Otherwise, C57BL/6 mouse liver sinusoidal endothelial cell is a useful tool to illuminate hepatic diseases or complications, such as non-alcoholic fatty liver disease (NAFLD), chronic liver injury, liver fibrosis, and liver metastasis. Moreover, these cells can be also widely used in other diseases at extrahepatic sites, such as atherosclerosis, glomerular fibrotic nephrosis, and systemic lupus erythematosus (SLE) due to their role in the clearance of select substances from the blood.

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