For research use only
| Cat No. | ABC-TC060S |
| Product Type | Mouse Lymphocytes Cell Lines |
| Species | Mouse- C3H |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Product Code | BA/F3; BaF3; BAF3; Baf3 |
Ba/F3 murine pro-B cells depend on IL-3, non-tumorigenic unless transformed, near-diploid, used for oncogene function, cytokine signaling, and drug assays.
Ba/F3 is a murine pro-B lymphocyte cell line established from C3H/HeJ mouse bone marrow (H-2k haplotype). These cells grow in suspension with a small, round morphology and high proliferation rates. Ba/F3 is dependent on interleukin-3 (IL-3) for survival (STAT5), undergoing apoptosis in its absence unless transformed by oncogenic stimuli, making them an invaluable tool for studying cytokine receptor signaling and kinase-driven transformation. Genetically, the line maintains stable karyotype (40, XY[67%]) facilitate consistent experimental outcomes. They lack endogenous expression of the prolactin receptor and certain cytokine receptors, though these can be introduced experimentally. While not inherently tumorigenic or metastatic, Ba/F3 cells may acquire these traits upon transformation. This cell line is widely used in studies of cytokine signaling, oncogenes, and drug screening.
| Product Code | BA/F3; BaF3; BAF3; Baf3 |
| Species | Mouse- C3H |
| Cat.No | ABC-TC060S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Lymphocytes Cell Lines |
Ba/F3 cells are extensively used as a model system to investigate cytokine receptor biology, signal transduction, and oncogenic kinase activity. Their IL-3 dependence and ability to be transformed by constitutively active kinases make them ideal for evaluating kinase inhibitors and understanding leukemia and lymphoma pathogenesis. Researchers also employ Ba/F3 cells for drug screening and resistance mechanism studies, as well as for validating the functional consequences of genetic mutations in hematopoietic signaling pathways.
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