Alpha TC1-9
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The Alpha TC1-9 cell line, a pancreatic alpha cell clone, was derived from the Alpha TC1 line, established in transgenic mice expressing the SV40 large T antigen oncogene under the rat preproglucagon promoter. Alpha TC1-9 exhibits MHC heterozygosity from both parental strains. Unlike the parent Alpha TC1, it specializes in producing glucagon and does not generate insulin or preproinsulin mRNA. Glucagon synthesis is individually inhibited by rat recombinant gamma-interferon or mouse recombinant interleukin-1 in Alpha TC1-9, without affecting DNA synthesis. These cells grow with poor attachment, often forming clusters that can become suspended. They have low viability and tend to clump, making accurate counting difficult. The cells typically appear rounded and are mostly in suspension, occasionally forming small clusters.
Why choose Alpha TC1-9 from AcceGen?
The Alpha TC1-9 cell line is characterized by exceptional viability and quality, cultivated under optimal conditions, and cryopreserved by proficient operators to ensure its integrity. Additionally, it is maintained in a sterile environment and rigorously tested, confirming its freedom from bacteria, yeast, and mycoplasma contamination.
| Product Code | alpha TC1 clone 9; alphaTC clone 9; alpha-TC1.9; alphaTC1.9; alpha-TC1-9; aTC1 Clone 9; aTC1-9 |
| Species | Mouse. (C57BL/6J X DBA/2)F2 (Transge |
| Cat.No | ABC-TC230S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | α Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Islet Cell Adenoma |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The Alpha TC1-9 cell line offers a versatile platform for multifaceted research endeavors. It facilitates in-depth investigations into glucagon biosynthesis and the responsiveness of alpha cells to cytokines, contributing to a comprehensive understanding of the intricate regulatory mechanisms governing glucose sensing and glucagon secretion in pancreatic alpha cells. Furthermore, it plays a crucial role in elucidating the impacts of metabolism-disrupting compounds on pancreatic alpha-cell biology. Notably, this cell line presents a valuable avenue for probing the potential conversion of alpha-cells into beta-cells, thus holding significant promise for advancing our knowledge of beta-cell regeneration and its implications in the context of diabetes research and therapy.
