92.1
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The 92.1 cell line originates from a primary uveal melanoma found in the right orbit of a 76-year-old female. When observed under light microscopy, the cultured cells display marked pleomorphism with prominent nucleoli, and they possess an in vitro doubling time of around 58 hours. Cytogenetic analysis has uncovered numerical abnormalities in chromosome 8 and structural abnormalities in chromosome 6. Notably, the 92.1 cell line exhibits the presence of the melanoma-associated antigen gp100, along with various other melanoma markers, such as Melan-A/MART-1, tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, and MCSP-1. Additionally, it demonstrates reduced levels of HLA-B mRNA when compared to HLA-A, alongside elevated c-myc expression.
Why choose 92.1 from AcceGen?
Choose 92.1 from AcceGen for unrivaled reliability: exceptional viability and quality ensured through optimal incubation, strict sterility measures, and rigorous quality control. Its authenticity is confirmed via Short Tandem Repeat (STR) profiling, guaranteeing accurate identification and consistent performance.
| Species | Human |
| Cat.No | ABC-TC444S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The 92.1 cell line holds significant applications in various fields of research. It serves as an invaluable tool for studying uveal melanoma and its molecular characteristics, aiding in the understanding of its progression and metastasis. Moreover, it plays a crucial role in investigating tumor suppressors in uveal melanoma. The cell line is also utilized as a model for anti-proliferation assays with anticancer drugs, enabling researchers to assess potential treatment options. Additionally, 92.1 cells are employed in forming three-dimensional (3D) spheroids for drug screening, allowing for more accurate and relevant evaluations. Furthermore, they are instrumental in establishing xenograft models of human uveal melanoma, proving to be effective in screening large compound libraries during drug discovery studies.
