For research use only
| Cat No. | ABC-TC0020 |
| Product Type | Human Thyroid Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Disease | Thyroid Cancer |
| Product Code | 8505c |
8505C is a human anaplastic thyroid carcinoma cell line used extensively for aggressive cancer research, drug resistance, and gene expression studies.
8505C is a human thyroid carcinoma cell line that was originally isolated from a 78-year-old female patient with anaplastic thyroid carcinoma. 8505C exhibits epithelial-like morphology and adherent culture properties. 8505C cells display aggressive tumor characteristics typical of anaplastic thyroid cancer, including high proliferation and invasive potential. They express epithelial-to-mesenchymal transition (EMT) markers, such as reduced E-cadherin and elevated vimentin, reflecting their dedifferentiated phenotype. Genetically, 8505C cells harbor mutations in key oncogenes and tumor suppressors, including TP53 and BRAF, contributing to their malignant behavior. This cell line is widely used as a model to study the biology, molecular mechanisms, and therapeutic responses of anaplastic thyroid carcinoma, one of the most lethal thyroid cancers.
| Product Code | 8505c |
| Species | Human |
| Cat.No | ABC-TC0020 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Disease | Thyroid Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Thyroid Cancer Cell Lines |
The 8505C cell line plays a critical role in thyroid cancer research. It is frequently used to evaluate potential drugs that induce or inhibit apoptosis in thyroid carcinoma cells. Moreover, it supports studies on the involvement of p53 mutations in malignant transformation, providing insight into the molecular pathways driving thyroid cancer progression and contributing to the development of new therapeutic approaches.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
8505C cell line is not an LMO (Living Modified Organism).
It has not been genetically modified but contains a p53 gene mutation.
