4T1
1
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The 4T1 cell line is a highly aggressive breast cancer model obtained from the mammary gland tissue of a mouse BALB/c strain. These cells possess remarkable tumorigenicity and invasiveness, with the ability to spontaneously metastasize from the primary tumor in the mammary gland to various distant sites, including lymph nodes, blood, liver, lung, brain, and bone. The proliferation of tumors and the subsequent spread of 4T1 cells in BALB/c mice closely mimic the growth and metastasis observed in human breast cancer. These cells exhibit molecular characteristics resembling human triple-negative breast cancer, as they lack the expression of estrogen receptor (ER), progesterone receptor (PgR), and epidermal growth factor receptor 2 (ErbB2).
Why choose 4T1 from AcceGen?
Choosing 4T1 cells from AcceGen is advantageous due to their high viability and quality. These cells are incubated under optimal and standardized conditions by professional operators, ensuring reliable and consistent results. Additionally, we implement rigorous quality control measures to guarantee the integrity and reliability of the 4T1 cell line.
| Product Code | 4T1-A; 4T1.0; 4T1/WT |
| Species | Mouse |
| Cat.No | ABC-TC0014 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Breast Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The 4T1 cell line derived from murine mammary carcinoma is extensively utilized as a syngeneic tumor model for studying human breast cancer. Serving as an animal model for stage IV breast cancer, 4T1-induced tumors offer applications as both a post-operative and nonsurgical model. This cell line possesses several characteristics that make it a valuable experimental model for studying mammary cancer. Notably, the ease of transplanting tumor cells into the mammary gland allows for the growth of primary tumors in the anatomically correct site. Furthermore, 4T1 cells exhibit spontaneous development of metastatic disease from the primary tumor, closely resembling human breast cancer.
