Subcellular Fractions

Subcellular fractions are isolated components of cells, such as organelles or specific cellular structures, used in drug discovery and preclinical development to study drug metabolism. These fractions are biologically active and can be stored for future research. By separating cellular compartments, researchers can focus on specific organelles, proteins, or structures within their physiological context. This enables detailed investigations into processes like protein synthesis, DNA replication, RNA splicing, muscle contraction, and vesicular transport. Additionally, subcellular fractions aid in exploring key cellular functions such as microtubule assembly and the role of mitochondria and chloroplasts in energy conversion, providing valuable insights into cell biology and disease mechanisms.