Cre Expressing Cells

Cre recombinase is a highly versatile enzyme that plays a crucial role in site-specific DNA recombination. Originating from the P1 bacteriophage, Cre recombinase mediates recombination between two specific DNA recognition sites known as loxP sites. Each loxP site consists of a 34 base pair sequence, composed of two 13 bp palindromic sequences flanking an asymmetric 8 bp spacer region. Depending on the orientation and position of these loxP sites, Cre recombinase can either excise the DNA between them, resulting in a circular plasmid containing the excised DNA, or fuse two DNA fragments. This reaction operates at equilibrium, does not require additional cofactors, and functions both in vitro and in vivo across a wide range of organisms, making the Cre/loxP system a powerful tool in biotechnology. AcceGen has developed over 70 Cre Expressing Cells to facilitate advanced genetic research. Please explore our extensive list of available cells below. If you require customized cells, please visit our Cell Custom Service or contact us directly at [email protected].