Cas9 Expressing Cells

Cas9 is a powerful DNA endonuclease that is central to the type II CRISPR-Cas system, revolutionizing the field of genome engineering. While several variants of Cas9 have been identified across different bacterial species, the Cas9 enzyme from Streptococcus pyogenes (SpCas9) is the most widely used and extensively studied for its structural and functional properties. SpCas9 has become a cornerstone in genome-editing technologies, enabling precise genetic modifications in a wide range of model organisms. In research, Cas9 has been used to create small genomic insertions and deletions (indels) through nonhomologous end-joining, as well as to facilitate larger sequence modifications via homologous recombination. Furthermore, Cas9 enables multiplexed genome engineering and has been used for the creation of extensive knock-out libraries in human cells, a process remarkable for its simplicity and high effectiveness. AcceGen offers a selection of Cas9 Expressing Cells to support your genome-editing endeavors. Explore our available cell lines in the list below. For specific requirements or customized cells, please visit our Cell Customization Service or reach out to us directly at [email protected].