Porcine Coronary Endothelial Cells are derived from healthly porcinine coronary arteries. Porcine Coronary Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in AcceGen’s Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately […]
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Porcine Coronary Endothelial Cells(PCAEC) are derived from healthly porcinine coronary arteries. which is the inner lining of the coronary arteries in pigs (porcine species). PCAEC represent a useful in vitro model to study biological and physiopathological properties of vascular endothelium. The endothelium is a vital component of blood vessels and plays a crucial role in maintaining vascular health. Endothelial cells are involved in various physiological functions, including regulating blood flow, preventing blood clotting, and influencing the immune response.
Why choose Porcine Coronary Endothelial Cells from AcceGen?
Derived from Healthy Porcine Coronary Arteries:
AcceGen’s PCAEC originates from robust and healthy porcine coronary arteries, ensuring a reliable cellular foundation.
Optimized Culturing Process:
They are cultivated in T25 tissue culture flasks with a meticulous pre-coating of a gelatin-based solution, and incubated in AcceGen’s Culture Complete Growth Medium for an optimized period of 3-7 days, fostering robust cellular development. Expanded cultures ensure an abundant supply of high-quality cells.
Precise Cryopreservation for Maximum Viability:
Cells are detached with precision from flasks before shipping. Immediate cryo-preservation in vials guarantees the preservation of cellular vitality. Each vial is richly endowed with a minimum of 1×10^6 cells per ml, delivered in a frozen state for optimum viability.
Species
Porcine
Cat.No
ABC-TC4032
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category
Primary Cells
Size/Quantity
1 vial
Cell Type
Endothelial
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Coronary
Disease
Normal
Biosafety Level
1
Storage
Liquid Nitrogen
Product Type
Porcine Primary Cells
Citation
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
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Application
FOR RESEARCH USE ONLY
PCAEC (Primary Coronary Artery Endothelial Cells) have played a pivotal role in uncovering mechanisms of obesity-associated vascular disease, elucidating pathways for endothelial relaxation, and evaluating the cardioprotective effects of a novel drug formulation through anti-inflammatory responses. Here are some applications of Porcine Coronary Endothelial Cells in science:
Obesity-Associated Vascular Disease Mechanism
Resistin, an adipocyte-derived cytokine linked to insulin resistance and diabetes, has been identified as a contributor to endothelial dysfunction in coronary arteries. Mechanism involves oxidative stress and down-regulation of NO synthase.
Endothelial Relaxation Pathway
Secretoneurin has been shown to activate the expression of NO synthase and calmodulin.
This activation leads to endothelial relaxation, suggesting a potential therapeutic target.
Anti-Inflammatory, Cardioprotective Effects
A novel adenosine-lidocaine drug formulation has demonstrated anti-inflammatory and cardioprotective effects. PCAEC were instrumental in adhesion and transmigration experiments, providing insights into the formulation’s impact on endothelial function.
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