Bovine Aortic Endothelial Cells

Bovine Aortic Endothelial Cells (BAECs) comprise a specialized cell lineage that envelops the luminal surface of the aorta, enduring persistent exposure to robust hemodynamic forces. These cells serve as pivotal regulators of vascular homeostasis by orchestrating the production of endothelium-derived substances, which intricately modulate vasoconstriction and vascular growth. Furthermore, BAECs exhibit a nuanced control over inflammatory responses and fibrinolysis through their capacity to modulate the expression of cellular adhesion molecules. Distinctly, BAECs manifest two reversible morphological phenotypes: when unencumbered by adhesive interactions, they adopt a polygonal configuration and form sheets, whereas comprehensive cell-surface adhesion induces an elongated, interconnected “sprouting” phenotype. Remarkably, these cells demonstrate migratory prowess, infiltrating collagen matrices from both apical and basal surfaces, ultimately culminating in the formation of distinctive, compact, three-dimensional meshworks within the gel milieu.

Why choose Bovine Aortic Endothelial Cells from AcceGen?

AcceGen offers Bovine Aortic Endothelial Cells (BAECs) derived from bovine aorta and cryopreserved at passage 2, with each vial containing over 0.5×10⁶ cells. These BAECs have been rigorously tested and are free from mycoplasma, bacteria, yeast, and fungal contaminants. They exhibit an impressive capacity for expansion, with the potential to undergo 16 population doublings under the conditions provided by AcceGen, making them ideal for various research applications.